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2C-B is a synthetic psychoactive substance of the phenethylamine family. Stimulant, empathogen, hallucinogen, and psychedelic are the various descriptions of this product. The compound draws comparisons to LSD and MDMA—though it’s not quite the same as either. Powder, tablet or capsule are the various forms of this product.
However, 2C-B is the best of the 2C-x group. Aphrodisiac, entheogen, dance drug, ecstasy adulterant, and psychotherapeutic aid are the uses of 2C-B.However, it has never gained widespread acceptance. Also,since the mid-1990s it has been legal in most countries.
2C-B was synthesized from 2,5-dimethoxybenzaldehyde by Alexander Shulgin in 1974. It first saw use among the psychiatric community as an aid during therapy. 2C-B was first sold commercially as a purported aphrodisiac under the trade name “Erox”, which was manufactured by the German pharmaceutical company Drittewelle. For several years, it was available as tablets in Dutch smart shops under the name “Nexus”.
2C-B first became popularized in the United States as a short-lived substitute for the street drug Ecstasy when MDMA became illegal in 1985. Many 2C-B users are young adults who attend raves. Though 2C-B is still used in the rave subculture, commonly mistaken for and/or sold as Ecstasy, its intentional use has become more common in the 2000s.
Street prices range between $10 and $30 per tablet in the United States in 2011 when purchased in small quantities. Larger retail purchases cost between $200 and $500 per gram. Wholesale purchases of 2C-B can lower the price ($100 to $300 per gram in 2001, $30 to $100 on the darknet in 2020).
A powder which has been dyed pink may be sold as “tucibi”, “tussi” or “pink cocaine”. This is not synonymous with 2C-B and instead refers to a mixture of drugs with pink dye. It is very rare for tusi to contain 2C-B, with the most common ingredients being ketamine, MDMA, and caffeine.
The September 1998 issue of Journal of Analytical Toxicology reported that very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-B. The relationship between its use and death are unknown. The common oral recreational dose is around 15–25 mg, at which visual and auditory effects are experienced. Severe adverse reactions are extremely rare, but use of 2C-B was linked to significant brain injury in one case report; the alleged “2C-B” was never actually discovered by testing so the only evidence suggesting 2C-B was the cause was the victim’s own words, and drug adulteration and toxic impurities are very common in illegal drugs.
|ED50||10 mg||4–6 mg|
|Moderate||15–25 mg||5–9 mg|
|Strong||26–35 mg||10–20 mg|
|Extremely Intense||>35 mg||>20 mg|
|Duration||4–8 hours||2–4 hours|
The lethal dosage is unknown. It was reported in PiHKAL, by Alexander Shulgin, that a psychologist had accidentally taken a 100 mg dose orally without apparent harm.
When sold as “Ecstasy”, tablets containing 2C-B often contain about 5 mg of the drug, an amount which produces stimulatory effects that mimic the effects of MDMA; in contrast, tablets marketed as 2C-B have larger quantities of the drug (10–20 mg) which cause hallucinogenic effects. Street purity of 2C-B, when tested, has been found to be relatively high. Researchers in Spain found that 2C-B samples in the country doubled between 2006 and 2009, switched from primarily powder form to tablets, and exhibited “low falsification rates”. An analysis of street samples in the Netherlands found impurities “in small percentages”; only one of the impurities, the N-acetyl derivative of 2C-B, could be identified, and comprised 1.3% of the sample. The authors suggested that this compound was a by-product of 2C-B synthesis.
Little academic research has been conducted on the effects of 2C-B in humans. The information available is largely anecdotal and limited. Effects are often described as being more easily managed than other psychedelics; it is often compared to a mixture of a serotonergic psychedelic and MDMA. At 5–10 mg, experiments with young chickens have shown it to produce effects similar to a low dosage of amphetamines.
The anecdotal effects of 2C-B that have been reported by users on online discussion forums include:
- At low doses, the experience may shift in intensity from engaging to mild/undetectable. Experienced users report the ability to take control of the effects and switch from engaged to sober at will.
- The hallucinations have a tendency to decrease and then increase in intensity, giving the users a sense of “waves” or even glowing. These are popularly described as “clichéd ’70s visuals” or objects taking on “water color”-like textures.
- While the effects of the drug often render users unable to concentrate deeply on anything in particular, some can become engrossed in an activity such as watching a movie or playing a video game, distracting themselves from the visual and auditory effects of the drug.
- Excessive giggling or smiling is common, as is a tendency for deeper “belly laughs”.
- Some users say that the effects are more intense when listening to music and report that they can see sounds and noises.
- Some users experience a decrease in visual acuity, although others report sharper vision.
- Through increased awareness of one’s body, attention may be brought to perceived “imperfections” or internal body processes.
The following effects are highly dose-dependent.
- Open eye visuals (OEVs), such as cartoon-like distortions and red or green halos around objects. Closed eye visuals (CEVs) are more common than OEVs.
- Affects and alters ability to communicate, engage in deep thought, or maintain attention span.
- Some users report experiencing frightening or fearful effects during the experience. Users describe feeling frigid or cold on reaching a plateau, while others feel wrapped in comfortable blankets/ultimate pleasure.
- Coordination may be affected, some users lose balance or have perceptual distinction problems.
- Onset time of 2C-B is highly dose dependent, but usually from 45 to 75 minutes. Taken on a full stomach, the onset time is increased to two hours or more.
- Before it was scheduled, 2C-B was sold in small doses as an aphrodisiac (see History). Some users report aphrodisiac effects at lower doses.
- Some users report mild “jitters” (body tremors), shuddering breath, and/or mild muscle spasms after insufflating 2C-B. Whether or not these effects are enjoyable depends on the user
- Mild to intense diarrhea, gas, nausea, and general gastrointestinal discomfort
- Severe headaches after coming down from large doses have been reported. However, many users report a lack of “comedown” or “crash”, instead noting a gradual return to sobriety
- At doses over 30–40 mg the user may experience frightening hallucinations, as well as tachycardia, hypertension, and hyperthermia
- 2C-B HCl is very painful to insufflate. Anecdotal evidence suggests that 2C-B HBr, the hydrobromide salt with greater water solubility, is less irritating to the mucous membranes lining the nose but slightly less potent when compared dose-for-dose with the HCl salt.
- Rectal administration of a water-based solution of 2C-B is known to be less painful than insufflation and much more potent than oral administration.
When orally consumed, 2C-B has a much longer delay before the onset of effects than when it is insufflated. Oral ingestion generally takes roughly 45–75 minutes for the effects to be felt, plateau lasts 2–4 hours, and coming down lasts 1–2 hours. Rectal administration onset varies from 5–20 minutes. Insufflated onset takes 1–10 minutes for effects to be felt. The duration can last from 4 to 12 hours depending on route of administration, dose, and other factors.
With insufflation, the effects are more abrupt and intense but have a significantly shorter duration, while oral usage results in a milder, longer experience. When insufflated, the onset happens very rapidly, usually reaching the peak at about 20–40 minutes and plateauing for 2–3 hours. 2C-B is also considered one of the most painful drugs to insufflate, with users reporting intense nasal burning. The sudden intensity of the experience combined with the pain can often start the experience with a negative imprint and nausea is also increased with insufflation, compounding the issue.
Unlike most psychedelics, 2C-B has been shown to be a low efficacy serotonin 5-HT2A receptor partial agonist or even full antagonist. This suggests that activation of the 5-HT2A-coupled phospholipase D pathway or functional antagonism of 5-HT2A may also play a role. The rank order of 5-HT2A receptor antagonist potency for this family of drugs is 2C-I > 2C-B > 2C-D > 2C-H.
Research suggests that 2C-B increases dopamine levels in the brains of rats, which may contribute to its psychoactivity.
2C-B has been shown to be metabolized by liver hepatocytes, resulting in deamination and demethylation that produces several products. Oxidative deamination results in the 2-(4-bromo-2,5-dimethoxyphenyl)-ethanol (BDMPE) and 4-bromo-2,5-dimethoxyphenylacetic acid (BDMPAA) metabolites. Additionally, 4-bromo-2,5-dimethoxybenzoic acid (BDMBA) can also be produced by oxidative deamination. Further metabolism of BDMPE and BDMPAA may occur by demethylation. Alternatively, the later metabolites can be generated by demethylation of 2C-B followed by oxidative deamination.
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